PLENARY SESSION ABSTRACTS QUALITY OF TRIALS Impact of a Systematic Review on Subsequent Clinical Research: The Case of the Prevention of Propofol Injection Pain

3 (a) Introduction: What does this case add? (b) Case presentation The primary symptoms of the patient The primary clinical findings The primary diagnoses and interventions The primary outcomes (c) Conclusion: What were the main “takeaway” lessons from this case? Introduction 4 Brief background summary of this case referencing relevant medical literature Patient Information 5 (a) Demographic information (eg, age, gender, ethnicity, occupation) (b) The presenting symptoms of the patient (his/her chief complaints) (c) Medical, family, and psychosocial history, including diet, lifestyle, and genetic information whenever possible, and details about relevant comorbidities including past interventions and their outcomes Clinical Findings 6 Describe the relevant physical examination (PE) findings. Timeline 7 Depict important dates and times in this case (table or figure). Diagnostic Assessment 8 (a) Diagnostic methods (eg, PE, laboratory testing, imaging, questionnaires) (b) Diagnostic challenges (eg, financial, language/cultural) (c) Diagnostic reasoning including other diagnoses considered (d) Prognostic characteristics (eg, staging) where applicable Therapeutic Intervention 9 (a) Types of intervention (eg, pharmacologic, surgical, preventive, self-care) Administration of intervention (eg, dosage, strength, duration) Changes in intervention (with rationale) Follow-up and Outcomes 10 (a) Summarize the clinical course of all follow-up visits including Clinicianand patient-assessed outcomes Important follow-up test results (positive or negative) Intervention adherence and tolerability (how this was assessed) Adverse and unanticipated events Discussion 11 (a) The strengths and limitations of the management of this case (b) The relevant medical literature (c) The rationale for conclusions (including assessments of cause and effect) (d) The main “takeaway” lessons of this case report Patient Perspective 12 The patient should share his or her perspective or experience whenever possible. Informed Consent 13 Did the patient give informed consent? Please provide if requested. Figure 7: Interventions Checklist Items Rating as Adequately Described, Initially and After Authors’ Reply In te rv en tio n Ra te d a s A d eq ua te ly D es cr ib ed , % Setting Overall Procedure Materials Intensity Schedule Provider Recipient After author contact Initially